Scd1^ab
Spontaneous Allele Detail

Summary

• Symbol: Scd1^ab
• Name: stearoyl-Coenzyme A desaturase 1; asebia
• MGI ID: MGI:1858028
• Gene: Scd1 Location: Chr19:44382889-44396148 bp, - strand Genetic Position: Chr19, 37.98 cM
• Alliance: Scd1^ab page

Mutation origin

• Strain of Origin: BALB/cCrglGa

Mutation description

• Allele Type: Spontaneous
• Mutation: Intragenic deletion
• Exons 1-4 deleted. (J:58283)
• Inheritance: Recessive

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Scd1^ab/Scd1^ab	involves: BALB/cCrglGa

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms Sex:
behavior/neurological	√	√
photophobia	√	√
endocrine/exocrine glands	√	√
sebaceous gland hypoplasia	√	√
growth/size/body	√	√
postnatal growth retardation	√	√
homeostasis/metabolism	√	√
photophobia	√	√
abnormal metabolism	√	√
integument	√	√
sebaceous gland hypoplasia	√	√
abnormal hair growth	√	√
alopecia	√	√
abnormal hair follicle morphology	√	√
abnormal hair follicle development	√	√
abnormal hair follicle inner root sheath morphology	√	√
abnormal piliary canal morphology	√	√
decreased hair follicle number	√	√
abnormal skin morphology	√	√
abnormal cutaneous collagen fibril morphology	√	√
abnormal cutaneous elastic fiber morphology	√	√
abnormal dermal layer morphology	√	√
hyperkeratosis	√	√
abnormal skin physiology	√	√
reproductive system	√	√
abnormal reproductive system physiology	√	√
abnormal estrous cycle	√
prolonged diestrus	√
reduced female fertility	√
vision/eye	√	√
photophobia	√	√
blindness	√	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scd1 Mutation: 23 strains or lines available

References

• Original: J:13143 Gates AH, et al., Hereditary absence of sebaceous glands in the mouse. Science. 1965;148:1471-1473
• All: 14 reference(s)