Fancc^tm1Mgo
Targeted Allele Detail

Summary

• Symbol: Fancc^tm1Mgo
• Name: Fanconi anemia, complementation group C; targeted mutation 1, Markus Grompe
• MGI ID: MGI:1858041
• Synonyms: fac^{deltaexon 9}
• Gene: Fancc Location: Chr13:63452519-63645126 bp, - strand Genetic Position: Chr13, 32.8 cM
• Alliance: Fancc^tm1Mgo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:61512
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced a genomic DNA fragment containing exon 9. RT-PCR analysis demonstrated that an abnormal transcript lacking only exon 9 was produced from this allele; however, no functional protein can be expressed from this mutant transcript. (J:61512)

Disease models

Expression

In Mice Carrying this Mutation:	24 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Fancc^tm1Mgo

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fancc Mutation: 68 strains or lines available

References

• Original: J:61512 Whitney MA, et al., Germ cell defects and hematopoietic hypersensitivity to gamma-interferon in mice with a targeted disruption of the Fanconi anemia C gene. Blood. 1996 Jul 1;88(1):49-58
• All: 14 reference(s)