Hr^Tg5053Mm
Transgenic Allele Detail

Summary

• Symbol: Hr^Tg5053Mm
• Name: lysine demethylase and nuclear receptor corepressor; transgene insertion 5053, Miriam Meisler
• MGI ID: MGI:1858045
• Synonyms: hr^TgN5053Mm
• Gene: Hr Location: Chr14:70789652-70810988 bp, + strand Genetic Position: Chr14, 36.32 cM
• Alliance: Hr^Tg5053Mm page

Transgene origin

• Strain of Origin: (C57BL/6 x C3H/He)F2

Transgene description

• Transgene Type: Transgenic
• Mutation: Insertion
• Mutation details: This allele was initially defined by a noncomplementation test with hr and subsequently found to be the result of the integration of a 2 kb construct, M2CAT ,containing an amylase/elastase enhancer/promoter, between intron 5 and exon 8 of the hairless gene, and deletion of the 3-prime portion of the gene (J:15642, J:57947)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hr Mutation: 87 strains or lines available

Notes

PCR analysis of flanking markers suggest that the transgene insertion site occurred in the C57BL/6J parent. This allele of Hr was induced by transgenic insertion of a construct with an amylase/elastase enhancer/promotor directing expression of the bacterial chloramphenicolacetyl transferase reporter gene. The clinical and histological phenotype of this mutant closely resembles the phenotype of rhino allele mutants (J:15642).

References

• Original: J:15642 Jones JM, et al., Insertional mutation of the hairless locus on mouse chromosome 14. Mamm Genome. 1993 Nov;4(11):639-43
• All: 2 reference(s)