Lep^ob-2J
Spontaneous Allele Detail

Summary

• Symbol: Lep^ob-2J
• Name: leptin; obese 2 Jackson
• MGI ID: MGI:1858048
• Synonyms: ob
• Gene: Lep Location: Chr6:29060220-29073875 bp, + strand Genetic Position: Chr6, 12.3 cM
• Alliance: Lep^ob-2J page

Mutation origin

• Strain of Origin: SM/Ckc-Fbxw4^Dac

Mutation description

• Allele Type: Spontaneous
• Mutation: Transposon insertion
• Mutation details: This allele is the result of an insertion of a full length early transposon, fusing exon 1 to the 3'LTR of the ETn. Northern analysis of adipose tissue RNA showed that the insertion provided alternative splice acceptor and polyadenylation sites producing fusion RNAs between the first exon and the retrovirus and precluding the expression of RNA from the coding sequence of Lep. (J:40727)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	1 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lep Mutation: 21 strains or lines available

References

• Original: J:30778 Sweet HO, et al., Remutations at The Jackson Laboratory (Update to Mouse Genome 1993; 91:862-5 - J16313). Mouse Genome. 1995;93(4):1030-4
• All: 3 reference(s)