Smad4^tm1Mak
Targeted Allele Detail

Summary

• Symbol: Smad4^tm1Mak
• Name: SMAD family member 4; targeted mutation 1, Tak Mak
• MGI ID: MGI:1858049
• Synonyms: Smad4^tm1Ari
• Gene: Smad4 Location: Chr18:73772080-73836851 bp, - strand Genetic Position: Chr18, 49.51 cM
• Alliance: Smad4^tm1Mak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:45399
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A neomycin resistance cassette replaced exon 8 and part of exon 9 of the gene. (J:45399)

Expression

In Mice Carrying this Mutation:	5 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Smad4^tm1Mak

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Smad4 Mutation: 48 strains or lines available

References

• Original: J:45399 Sirard C, et al., The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo. Genes Dev. 1998 Jan 1;12(1):107-19
• All: 6 reference(s)