Msh2^tm1Htr
Targeted Allele Detail

Summary

• Symbol: Msh2^tm1Htr
• Name: mutS homolog 2; targeted mutation 1, Hein Te Riele
• MGI ID: MGI:1858055
• Synonyms: Msh2-, Msh2^tm1Nki
• Gene: Msh2 Location: Chr17:87979960-88031141 bp, + strand Genetic Position: Chr17, 57.87 cM
• Alliance: Msh2^tm1Htr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:27469
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• A hygromycin resistance cassette was inserted between codons 588 and 589 of the gene. (J:27469)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Msh2^tm1Htr

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Msh2 Mutation: 95 strains or lines available

References

• Original: J:27469 de Wind N, et al., Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer. Cell. 1995 Jul 28;82(2):321-30
• All: 54 reference(s)