Msh3^tm1Rak
Targeted Allele Detail

Summary

• Symbol: Msh3^tm1Rak
• Name: mutS homolog 3; targeted mutation 1, Raju Kucherlapati
• MGI ID: MGI:1858056
• Synonyms: Msh3-
• Gene: Msh3 Location: Chr13:92348387-92491515 bp, - strand Genetic Position: Chr13, 47.63 cM
• Alliance: Msh3^tm1Rak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:60604
• Parent Cell Line: WW6 (ES Cell)
• Strain of Origin: STOCK 129/Sv and C57BL/6J and SJL

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance gene was inserted into exon 7 of the gene. No transcript for the targeted gene was detected on Northern blots of RNA extracted from livers of homozygous mutant mice. (J:60604)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Msh3^tm1Rak

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Msh3 Mutation: 61 strains or lines available

References

• Original: J:60604 Edelmann W, et al., The DNA mismatch repair genes Msh3 and Msh6 cooperate in intestinal tumor suppression. Cancer Res. 2000 Feb 15;60(4):803-7
• All: 11 reference(s)