Msh5^tm1Rak
Targeted Allele Detail

Summary

• Symbol: Msh5^tm1Rak
• Name: mutS homolog 5; targeted mutation 1, Raju Kucherlapati
• MGI ID: MGI:1858057
• Synonyms: Msh^-, Msh5^-
• Gene: Msh5 Location: Chr17:35247581-35265721 bp, - strand Genetic Position: Chr17, 18.57 cM
• Alliance: Msh5^tm1Rak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:51921
• Parent Cell Line: WW6 (ES Cell)
• Strain of Origin: STOCK 129/Sv and C57BL/6J and SJL

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A hygromycin resistance gene was inserted into exon 18, at codon 528, of the gene. No transcript for the targeted gene was detected on Northern blots of RNA extracted from testes of homozygous mutant mice. No protein product for the targeted gene was detected on Western blots of protein extracted from testes of homozygous mutant mice. (J:51921)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Msh5^tm1Rak

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Msh5 Mutation: 49 strains or lines available

References

• Original: J:51921 Edelmann W, et al., Mammalian MutS homologue 5 is required for chromosome pairing in meiosis. Nat Genet. 1999 Jan;21(1):123-7
• All: 11 reference(s)