Tg(CAMalpha1b)7Wjk
Transgene Detail
|
Symbol: |
Tg(CAMalpha1b)7Wjk |
Name: |
transgene insertion 7, Walter Koch |
MGI ID: |
MGI:1858099 |
Synonyms: |
CAM7, (CAM)alpha1B-AR, CAMalpha1B-AR |
Transgene: |
Tg(CAMalpha1b)7Wjk Location: unknown
|
Alliance: |
Tg(CAMalpha1b)7Wjk page
|
|
Strain of Origin: |
Not Specified
|
|
Transgene Type: |
|
Transgenic (Constitutively active, Inserted expressed sequence) |
Mutation: |
|
Insertion
|
|
|
Tg(CAMalpha1b)7Wjk expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Note |
hamster |
Adra1b (101843941) |
|
|
|
|
Mutation details: Sequence encoding hamster adrenergic receptor alpha 1b (ADRA1B), containing 3 missense mutations (R288K, K290H, A293L) to make it constitutively active, was adjoined to the mouse myosin, heavy polypeptide 6, cardiac muscle, alpha (Myh6) promoter. Cardiac-specific expression of the mutant ADRA1B was indicated by radio ligand binding assay to be approximately 3-fold higher than that of the endogenous Adra1b. In addition to line 7 (CAM7), lines 21 (CAM21) and 56 (CAM56) were also generated. They also overexpress by approximately 3-fold.
(J:82721)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
|
|
Original: |
J:82721 Milano CA, et al., Myocardial expression of a constitutively active alpha 1B-adrenergic receptor in transgenic mice induces cardiac hypertrophy. Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):10109-13 |
All: |
4 reference(s) |
|