Apc^tm1Rfo
Targeted Allele Detail

Summary

• Symbol: Apc^tm1Rfo
• Name: APC, WNT signaling pathway regulator; targeted mutation 1, Riccardo Fodde
• MGI ID: MGI:1858101
• Synonyms: APC1638T
• Gene: Apc Location: Chr18:34353977-34455605 bp, + strand Genetic Position: Chr18, 18.53 cM
• Alliance: Apc^tm1Rfo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:55416
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutation: Insertion
• Mutation details: A hygromycin expression cassette was inserted into exon 15 at codon 1638. The hygromycin cassette was inserted in the same transcriptional orientation as the Apc gene. A 182 kDa truncated protein is stably expressed from this allele. (J:55416)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Apc^tm1Rfo

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Apc Mutation: 158 strains or lines available

References

• Original: J:55416 Smits R, et al., Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development. Genes Dev. 1999 May 15;13(10):1309-21
• All: 6 reference(s)