Brca1^tm1Whl
Targeted Allele Detail

Summary

• Symbol: Brca1^tm1Whl
• Name: breast cancer 1, early onset; targeted mutation 1, Weu-Hwa Lee
• MGI ID: MGI:1858107
• Synonyms: Brca1 (-), Brca1^ko
• Gene: Brca1 Location: Chr11:101379590-101442781 bp, - strand Genetic Position: Chr11, 65.18 cM, cytoband D
• Alliance: Brca1^tm1Whl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:34458
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 184 bp fragment of the Brca1 gene corresponding to amino acids 300-361 was deleted and replaced with a neomycin cassette. (J:34458)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Brca1^tm1Whl

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Brca1 Mutation: 114 strains or lines available

References

• Original: J:34458 Liu CY, et al., Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development. Genes Dev. 1996 Jul 15;10(14):1835-43
• All: 3 reference(s)