Brca1^tm1Mak
Targeted Allele Detail

Summary

• Symbol: Brca1^tm1Mak
• Name: breast cancer 1, early onset; targeted mutation 1, Tak Mak
• MGI ID: MGI:1858108
• Synonyms: Brca1^5-6
• Gene: Brca1 Location: Chr11:101379590-101442781 bp, - strand Genetic Position: Chr11, 65.18 cM, cytoband D
• Alliance: Brca1^tm1Mak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:33880
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Replacement of exons 5 and 6, encoding the zinc finger domain, with a neomycin cassette. (J:33880)

Expression

In Mice Carrying this Mutation:	17 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Brca1^tm1Mak

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Brca1 Mutation: 114 strains or lines available

References

• Original: J:33880 Hakem R, et al., The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse. Cell. 1996 Jun 28;85(7):1009-23
• All: 2 reference(s)