Fech^m1Pas
Chemically induced Allele Detail

Summary

• Symbol: Fech^m1Pas
• Name: ferrochelatase; ferrochelatase deficiency, mutation 1, Institut Pasteur
• MGI ID: MGI:1858114
• Synonyms: fch
• Gene: Fech Location: Chr18:64589613-64622169 bp, - strand Genetic Position: Chr18, 37.43 cM
• Alliance: Fech^m1Pas page

Mutation origin

• Strain of Origin: 129/Sv x BALB/c

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This mutation is a T-to-A transversion at position 293, resulting in a methionine to lysine substitution at position 98 of the encoded protein. (J:12757)
• Inheritance: Recessive

Disease models

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Fech^m1Pas

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Fech Mutation: 24 strains or lines available

References

• Original: J:2021 Tutois S, et al., Erythropoietic protoporphyria in the house mouse. A recessive inherited ferrochelatase deficiency with anemia, photosensitivity, and liver disease. J Clin Invest. 1991 Nov;88(5):1730-6
• All: 21 reference(s)