Hba^th-J
Chemically induced Allele Detail

Summary

• Symbol: Hba^th-J
• Name: hemoglobin alpha chain complex; alpha thalassemia Jackson
• MGI ID: MGI:1858115
• Synonyms: alpha^MD
• Gene: Hba Location: unknown Genetic Position: Chr11, cytoband A

Mutation origin

• Strain of Origin: C57BL/6J x Triethyllenemelamine-treated male

Mutation description

• Allele Type: Chemically induced (other)
• Mutation: Intergenic deletion
• Hba^th-J involves 6 genes/genome features (Rhbdf1, Mpg, Nprl3 ...) View all
• Mutation details: This mutation was shown to be a deletion that included the Hba-x, Hba-a1 and Hba-a2 genes (J:32654). The Mpg, Rhbdf1 and Phg genes are also included in the deletion region (J:29665). (J:29665, J:32654)
• Inheritance: Codominant

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Hba^th-J/Hba^th-J	involves: C57BL/6J
ht2	Hba^th-J/Hba^+	B6.Cg-Hba^th-J
ht3  Disease Model	Hba^th-J/Hba^+	involves: C57BL/6J
cx4	Hba-a1^tm1Ywk/Hba^th-J	involves: 129X1/SvJ * C57BL/6J

Phenotypes:

Affected Systems	hm1	ht2	ht3	cx4
show or hide all annotated terms
cellular		√
maternal effect		√
embryo	√
abnormal blastocyst morphology	√
abnormal inner cell mass morphology	√
abnormal trophectoderm morphology	√
growth/size/body			√	√
decreased body weight			√
decreased fetal size				√
hematopoietic system			√	√
hemolytic anemia				√
abnormal erythrocyte morphology				√
increased erythrocyte cell number			√
abnormal hemoglobin				√
decreased hemoglobin content			√
anisocytosis				√
leptocytosis				√
microcytosis			√
poikilocytosis				√
polychromatophilia				√
reticulocytosis				√
integument				√
pallor				√
mortality/aging	√		√	√
perinatal lethality, complete penetrance				√
postnatal lethality			√
embryonic lethality between implantation and somite formation, complete penetrance	√

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Key:

√

disease model

expected model not found

Models:

Human Diseases	ht3
alpha thalassemia IDs alpha thalassemia       DOID:1099 ICD10CM:D56.0 ICD9CM:282.43 MESH:D017085 NCI:C34368 OMIM:604131 UMLS_CUI:C0002312 Close	√

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Hba Mutation: 10 strains or lines available

Notes

The mutation was induced in a male mouse by triethyllenemelamine.

References

• Original: J:45721 Whitney JB, et al., New mutants and biochemical variants: Alpha thalassemia. Mouse News Lett. 1978;58:47-48
• All: 12 reference(s)