Tap1^tm1Hpl
Targeted Allele Detail

Summary

• Symbol: Tap1^tm1Hpl
• Name: transporter 1, ATP-binding cassette, sub-family B (MDR/TAP); targeted mutation 1, Hidde Ploegh
• MGI ID: MGI:1858161
• Synonyms: TAP1⁰
• Gene: Tap1 Location: Chr17:34406530-34416199 bp, + strand Genetic Position: Chr17, 17.98 cM
• Alliance: Tap1^tm1Hpl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:60782
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequences encoding the second and part of the third transmembrane helices were replaced by a neomycin resistance gene. (J:60782)
• Inheritance: Recessive

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Tap1^tm1Hpl

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tap1 Mutation: 51 strains or lines available

References

• Original: J:60782 Tourne S, et al., Biosynthesis of major histocompatibility complex molecules and generation of T cells in Ii TAP1 double-mutant mice. Proc Natl Acad Sci U S A. 1996 Feb 20;93(4):1464-9
• All: 20 reference(s)