Gnb5^flr
Spontaneous Allele Detail

Summary

• Symbol: Gnb5^flr
• Name: guanine nucleotide binding protein (G protein), beta 5; flailer
• MGI ID: MGI:1858521
• Synonyms: flail, flr, tb^2J
• Gene: Gnb5 Location: Chr9:75213570-75253158 bp, + strand Genetic Position: Chr9, 42.3 cM
• Alliance: Gnb5^flr page

Mutation origin

• Strain of Origin: C57BL/10J x B6CBA/Ca

Mutation description

• Allele Type: Spontaneous
• Mutation: Other
• Mutation details: Hybrid. This mutation is caused by gene shuffling between Gnb5 and Myo5a. The shuffling combines the promoter of the first two exons of Gnb5 with the C-terminal exons of Myo5a. Flailer homozygotes express transcripts of three genes: wild-type Gnb5, wild-type Myo5a and the flailer hybrid gene. (J:61324)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Gnb5 Mutation: 24 strains or lines available

Notes

The flailer mutation, originally called tb^2J, was a presumed remutation of tb because of a similar phenotype. This mutation, however, does not map to Chr 1, and the original unpublished report of linkage of tb to Chr 1 is in doubt. Thus, it is not clear whether tb^2J is a remutation at the tb locus which was not on Chr 1, or if tb^2J is a new mutation at a different locus. Because of its linkage to a different chromosome, tb^2J was renamed flr.

flr mutants have a variable neurological phenotype. Half of all flailer homozygotes show severe ataxia and only live for 3 weeks; these mutants tend to fall over and flail their limbs in an effort to right themselves. The other half of flailer homozygotes, however, only develop a transient ataxia; they recover, are fertile, and have a normal life span.

References

• Original: J:30778 Sweet HO, et al., Remutations at The Jackson Laboratory (Update to Mouse Genome 1993; 91:862-5 - J16313). Mouse Genome. 1995;93(4):1030-4
• All: 6 reference(s)