Rag2^tm1Fwa
Targeted Allele Detail

Summary

• Symbol: Rag2^tm1Fwa
• Name: recombination activating gene 2; targeted mutation 1, Frederick W Alt
• MGI ID: MGI:1858556
• Synonyms: Rag2-, RAG-2-, RAG2 KO, Rag2M, Rag2^tm1Alt, Rag2^tm1Fwe
• Gene: Rag2 Location: Chr2:101455063-101462874 bp, + strand Genetic Position: Chr2, 53.87 cM
• Alliance: Rag2^tm1Fwa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:1935
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced a 0.85kb segment of the open reading frame, eliminating the encoding of 286 of the 527 amino acids of the protein. (J:1935)

Disease models

Expression

In Mice Carrying this Mutation:	19 assay results 6 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	10 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Rag2^tm1Fwa

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 45 strains available Cell Lines: 0 lines available
• Carrying any Rag2 Mutation: 119 strains or lines available

References

• Original: J:1935 Shinkai Y, et al., RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell. 1992 Mar 6;68(5):855-67
• All: 997 reference(s)