Trim28^tm1.2Ipc
Targeted Allele Detail

Summary

• Symbol: Trim28^tm1.2Ipc
• Name: tripartite motif-containing 28; targeted mutation 1.2, Pierre Chambon
• MGI ID: MGI:1859550
• Synonyms: L-, Tif1b-, TIF1beta^-
• Gene: Trim28 Location: Chr7:12758079-12764959 bp, + strand Genetic Position: Chr7, 7.73 cM, cytoband A2
• Alliance: Trim28^tm1.2Ipc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:62628
• Parent Cell Line: H1 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Deletion of exons 4-14 of the coding region as follows: A PGK-neomycin cassette flanked by two loxP sites was introduced into intron 3 and a loxP site was introduced into exon 14. Mice positive for the presence of this allele were mated to CMV-Cre transgenic mice to generate mice in which the loxP flanked sequences were deleted. (J:62628)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	5 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trim28 Mutation: 36 strains or lines available

References

• Original: J:62628 Cammas F, et al., Mice lacking the transcriptional corepressor TIF1beta are defective in early postimplantation development. Development. 2000 Jul;127(13):2955-63
• All: 5 reference(s)