Fgf10^tm1Ska
Targeted Allele Detail

Summary

• Symbol: Fgf10^tm1Ska
• Name: fibroblast growth factor 10; targeted mutation 1, Shigeaki Kato
• MGI ID: MGI:1859647
• Synonyms: fgf10-
• Gene: Fgf10 Location: Chr13:118851199-118928651 bp, + strand Genetic Position: Chr13, 67.14 cM, cytoband A3-A4
• Alliance: Fgf10^tm1Ska page

Submandibular gland abnormalities in Fgf10^tm1Ska/Fgf10^tm1Ska and Fgfr2^tm1.1Dsn/Fgfr2^tm1.1Dsn mice at E12.5

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:51966
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced 1.1 kb of sequence that contains the exon encoding the ATG translation initiation site and the amino terminal 110 amino acids of the encoded protein. (J:51966)

Disease models

Expression

In Mice Carrying this Mutation:	144 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	53 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fgf10 Mutation: 33 strains or lines available

References

• Original: J:51966 Sekine K, et al., Fgf10 is essential for limb and lung formation. Nat Genet. 1999 Jan;21(1):138-41
• All: 57 reference(s)