Adrb2^tm1Bkk
Targeted Allele Detail

Summary

• Symbol: Adrb2^tm1Bkk
• Name: adrenergic receptor, beta 2; targeted mutation 1, Brian K Kobilka
• MGI ID: MGI:1859675
• Synonyms: Adrb2^-, Beta2-AR, beta2AR^-, Beta2-KO
• Gene: Adrb2 Location: Chr18:62310887-62313030 bp, - strand Genetic Position: Chr18, 35.1 cM
• Alliance: Adrb2^tm1Bkk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:55552
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette was inserted into the sequence encoding the fourth transmembrane segment. This mutation is predicted to eliminate expression of a functional receptor. Ligand binding experiments confirmed that no functional receptor was expressed in the lung of homozygous mice. (J:55552)

Disease models

Expression

In Mice Carrying this Mutation:	104042 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Adrb2 Mutation: 34 strains or lines available

References

• Original: J:55552 Chruscinski AJ, et al., Targeted disruption of the beta2 adrenergic receptor gene. J Biol Chem. 1999 Jun 11;274(24):16694-700
• All: 164 reference(s)