Slc30a3^tm1Rpa
Targeted Allele Detail

Summary

• Symbol: Slc30a3^tm1Rpa
• Name: solute carrier family 30 (zinc transporter), member 3; targeted mutation 1, Richard D Palmiter
• MGI ID: MGI:1859820
• Synonyms: Znt3^-, ZnT3
• Gene: Slc30a3 Location: Chr5:31243450-31265576 bp, - strand Genetic Position: Chr5, 16.97 cM
• Alliance: Slc30a3^tm1Rpa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:53059
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 through 4 were replaced with a cassette containing nuclear lacZ and neo. Encoded protein was undetectable in brain homogenates from homozygous mutant mice via Western blot analysis. Beta-galactosidase expression was used to observe the activity of the endogenous promoter. (J:53059)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc30a3 Mutation: 28 strains or lines available

References

• Original: J:53059 Cole TB, et al., Elimination of zinc from synaptic vesicles in the intact mouse brain by disruption of the ZnT3 gene. Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1716-21
• All: 55 reference(s)