Xpc^tm1Ecf
Targeted Allele Detail

Summary

• Symbol: Xpc^tm1Ecf
• Name: xeroderma pigmentosum, complementation group C; targeted mutation 1, Errol C Friedberg
• MGI ID: MGI:1859840
• Synonyms: Xpc-
• Gene: Xpc Location: Chr6:91466287-91492870 bp, - strand Genetic Position: Chr6, 40.55 cM, cytoband D
• Alliance: Xpc^tm1Ecf page

Lungs of Xpc^tm1Ecf/Xpc^tm1Ecf mice show a range of lesions

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:38645
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exon 10 of the Xpc gene, and portions of the flanking introns. The authors predict that homozygous mutant animals would produce a truncated polypeptide with 27 missense amino acids in place of the last 300 C-terminal amino acids. Northern analysis of primary MEF cells from homozygous mutant embryos detected two anomalous transcripts using an exon 7-10 probe, and no transcript using an exon 11-15 probe. (J:38645)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Xpc^tm1Ecf

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Xpc Mutation: 34 strains or lines available

References

• Original: J:38645 Cheo DL, et al., Characterization of defective nucleotide excision repair in XPC mutant mice. Mutat Res. 1997 Mar 4;374(1):1-9
• All: 51 reference(s)