Vax1^tm1Grl
Targeted Allele Detail

Summary

• Symbol: Vax1^tm1Grl
• Name: ventral anterior homeobox 1; targeted mutation 1, Greg Lemke
• MGI ID: MGI:1859863
• Synonyms: Vax1^-
• Gene: Vax1 Location: Chr19:59154619-59158488 bp, - strand Genetic Position: Chr19, 54.61 cM
• Alliance: Vax1^tm1Grl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:58996
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced exons 1 and 2, which encode the first 166 amino acids, including the initiator methionine and 46 residues of the homeodomain. An absence of transcript was determined via in situ hybridization of the ventral diencephalon region in homozygous mutant embryos. (J:58996)
• Inheritance: Semidominant

Expression

In Mice Carrying this Mutation:	14 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vax1 Mutation: 14 strains or lines available

References

• Original: J:58996 Bertuzzi S, et al., The homeodomain protein vax1 is required for axon guidance and major tract formation in the developing forebrain. Genes Dev. 1999 Dec 1;13(23):3092-105
• All: 12 reference(s)