Trp73^tm1Fmc
Targeted Allele Detail

Summary

• Symbol: Trp73^tm1Fmc
• Name: transformation related protein 73; targeted mutation 1, Frank McKeon
• MGI ID: MGI:1859911
• Synonyms: p73 -
• Gene: Trp73 Location: Chr4:154140706-154224332 bp, - strand Genetic Position: Chr4, 83.79 cM
• Alliance: Trp73^tm1Fmc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:60896
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 5 and a portion of exon 6, encoding part of the DNA binding domain, and the neighboring intronic sequences were replaced by a neomycin gene. (J:60896)

Disease models

Expression

In Mice Carrying this Mutation:	45 assay results
In Structures Affected by this Mutation:	17 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Trp73^tm1Fmc

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trp73 Mutation: 46 strains or lines available

References

• Original: J:60896 Yang A, et al., p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours. Nature. 2000 Mar 2;404(6773):99-103
• All: 46 reference(s)