Tulp1^tm1Pjn
Targeted Allele Detail

Summary

• Symbol: Tulp1^tm1Pjn
• Name: TUB like protein 1; targeted mutation 1, Patsy M Nishina
• MGI ID: MGI:1859921
• Synonyms: Tulp1^-
• Gene: Tulp1 Location: Chr17:28570489-28584190 bp, - strand Genetic Position: Chr17, 14.66 cM
• Alliance: Tulp1^tm1Pjn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:59884
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 8 and 9 were replaced by a neomycin selection cassette. Western blot analysis revealed an absence of encoded protein in the retinas and brains and brains of homozygous mutant mice. Immunofluorescence analysis of retinal tissue confirmed the blotting analysis. (J:59884, J:79602)

Disease models

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tulp1 Mutation: 41 strains or lines available

References

• Original: J:59884 Ikeda S, et al., Retinal degeneration but not obesity is observed in null mutants of the tubby-like protein 1 gene. Hum Mol Genet. 2000 Jan 22;9(2):155-63
• All: 15 reference(s)