Vax1^tm1Pgr
Targeted Allele Detail

Summary

• Symbol: Vax1^tm1Pgr
• Name: ventral anterior homeobox 1; targeted mutation 1, Peter Gruss
• MGI ID: MGI:1859922
• Synonyms: Vax1^-
• Gene: Vax1 Location: Chr19:59154619-59158488 bp, - strand Genetic Position: Chr19, 54.61 cM
• Alliance: Vax1^tm1Pgr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:58997
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A cassette containing lacZ and neo genes replaced the exon encoding the initiator methionine, all of the first two helices and a portion of the third helix of the homeodomain. The expression pattern of beta-galactosidase resembled that of the endogenous gene. (J:58997)

Expression

In Structures Affected by this Mutation:

18 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Vax1 Mutation: 14 strains or lines available

References

• Original: J:58997 Hallonet M, et al., Vax1, a novel homeobox-containing gene, directs development of the basal forebrain and visual system. Genes Dev. 1999 Dec 1;13(23):3106-14
• All: 3 reference(s)