Vpreb1a^tm1Ilm
Targeted Allele Detail

Summary

• Symbol: Vpreb1a^tm1Ilm
• Name: V-set pre-B cell surrogate light chain 1A; targeted mutation 1, Inga-Lill Martensson
• MGI ID: MGI:1859923
• Synonyms: VpreB1 -
• Gene: Vpreb1a Location: Chr16:16686265-16687119 bp, - strand Genetic Position: Chr16, 10.46 cM
• Alliance: Vpreb1a^tm1Ilm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:53512
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: All of exon 1 and a portion of exon 2 were replaced with a neomycin selection cassette. RT-PCR analysis confirmed that while Vpreb1 transcript was absent in homozygous mutant mice, normal levels of Vpreb2 were present. (J:53512)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vpreb1a Mutation: 24 strains or lines available

References

• Original: J:53512 Martensson A, et al., Partial block in B lymphocyte development at the transition into the pre-B cell receptor stage in Vpre-B1-deficient mice. Int Immunol. 1999 Mar;11(3):453-60
• All: 4 reference(s)