Tfrc^tm1Nca
Targeted Allele Detail

Summary

• Symbol: Tfrc^tm1Nca
• Name: transferrin receptor; targeted mutation 1, Nancy C Andrews
• MGI ID: MGI:1859944
• Synonyms: Trfr^-
• Gene: Tfrc Location: Chr16:32427738-32451612 bp, + strand Genetic Position: Chr16, 23.06 cM
• Alliance: Tfrc^tm1Nca page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:54107
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Coding sequence including exons 3 through 5 was replaced with a neomycin selection cassette. (J:54107)

Expression

In Mice Carrying this Mutation:	9 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tfrc Mutation: 64 strains or lines available

References

• Original: J:54107 Levy JE, et al., Transferrin receptor is necessary for development of erythrocytes and the nervous system. Nat Genet. 1999 Apr;21(4):396-9
• All: 6 reference(s)