Traf6^tm1Mak
Targeted Allele Detail

Summary

• Symbol: Traf6^tm1Mak
• Name: TNF receptor-associated factor 6; targeted mutation 1, Tak Mak
• MGI ID: MGI:1859953
• Synonyms: TRAF6^-
• Gene: Traf6 Location: Chr2:101508774-101532014 bp, + strand Genetic Position: Chr2, 53.9 cM
• Alliance: Traf6^tm1Mak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:54467
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The insertion of a neomycin selection cassette disrupted the exon encoding the translation initiation codon and the first 100 residues, which constitute the amino terminal portion of the zinc RING finger domain. Western blot analysis of renal immunoprecipitates and total renal lysates showed an absence of protein in homozygous mutant mice. (J:54467)

Expression

In Mice Carrying this Mutation:	41 assay results
In Structures Affected by this Mutation:	11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Traf6 Mutation: 34 strains or lines available

References

• Original: J:54467 Lomaga MA, et al., TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Genes Dev. 1999 Apr 15;13(8):1015-24
• All: 12 reference(s)