Traf5^tm1Hna
Targeted Allele Detail

Summary

• Symbol: Traf5^tm1Hna
• Name: TNF receptor-associated factor 5; targeted mutation 1, Hiroyasu Nakano
• MGI ID: MGI:1859960
• Synonyms: traf5^-
• Gene: Traf5 Location: Chr1:191729166-191776868 bp, - strand Genetic Position: Chr1, 97.11 cM
• Alliance: Traf5^tm1Hna page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:57114
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced by the insertion of a neomycin selection cassette. The deleted region encoded the carboxy terminal half of the zinc RING finger domain. Encoded protein was undetected in homozygous mutant mice by Western blot analysis of lung tissue lysates. (J:57114)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Traf5 Mutation: 27 strains or lines available

References

• Original: J:57114 Nakano H, et al., Targeted disruption of Traf5 gene causes defects in CD40- and CD27-mediated lymphocyte activation. Proc Natl Acad Sci U S A. 1999 Aug 17;96(17):9803-8
• All: 23 reference(s)