Tnp1^tm1Mlm
Targeted Allele Detail

Summary

• Symbol: Tnp1^tm1Mlm
• Name: transition protein 1; targeted mutation 1, Marvin L Meistrich
• MGI ID: MGI:1859961
• Synonyms: Tnp1-, Tnp1-null
• Gene: Tnp1 Location: Chr1:73054233-73055058 bp, - strand Genetic Position: Chr1, 36.94 cM
• Alliance: Tnp1^tm1Mlm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:61941
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire gene was replaced with a neomycin cassette, which was inserted in an antisense orientation. Tnp1 protein was not detectable in extracts of testicular homogenates from homozygous mutant mice. (J:61941)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tnp1 Mutation: 4 strains or lines available

References

• Original: J:61941 Yu YE, et al., Abnormal spermatogenesis and reduced fertility in transition nuclear protein 1-deficient mice. Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4683-8
• All: 6 reference(s)