Tnfrsf11a^tm1Imx
Targeted Allele Detail

Summary

• Symbol: Tnfrsf11a^tm1Imx
• Name: tumor necrosis factor receptor superfamily, member 11a, NFKB activator; targeted mutation 1, Immunex Research and Development Corporation
• MGI ID: MGI:1860238
• Synonyms: RANK-
• Gene: Tnfrsf11a Location: Chr1:105708443-105775709 bp, + strand Genetic Position: Chr1, 49.7 cM
• Alliance: Tnfrsf11a^tm1Imx page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:57899
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neo cassette was used to replace exons 4 through 7, which encode for the majority of both the extracellular domain and the transmembrane region. Southern blot analysis verified the targeting event. (J:57899)

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tnfrsf11a^tm1Imx

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnfrsf11a Mutation: 42 strains or lines available

Notes

ES cell line was not specified, but noted to be 129 derived.

References

• Original: J:57899 Dougall WC, et al., RANK is essential for osteoclast and lymph node development. Genes Dev. 1999 Sep 15;13(18):2412-24
• All: 14 reference(s)