Thrb^tm1Few
Targeted Allele Detail

Summary

• Symbol: Thrb^tm1Few
• Name: thyroid hormone receptor beta; targeted mutation 1, Fredric E Wondisford
• MGI ID: MGI:1860353
• Synonyms: TRbeta2 null
• Gene: Thrb Location: Chr14:4431611-4809435 bp, - strand Genetic Position: Chr14, 7.08 cM, cytoband A3
• Alliance: Thrb^tm1Few page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:56668
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neo cassette replaced the transcription site, the entire Thrb2-specific exon, and the splice donor acceptor site. RT-PCR analysis of pituitary RNA confirmed the preservation of the Thrb1 isoform, as well as the absence of the Thrb2 isoform. (J:56668)

Expression

In Mice Carrying this Mutation:	5 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Thrb Mutation: 41 strains or lines available

References

• Original: J:56668 Abel ED, et al., Divergent roles for thyroid hormone receptor beta isoforms in the endocrine axis and auditory system. J Clin Invest. 1999 Aug;104(3):291-300
• All: 2 reference(s)