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Thrbtm1Olc
Targeted Allele Detail
Summary
Symbol: Thrbtm1Olc
Name: thyroid hormone receptor beta; targeted mutation 1, Olivier Chassande
MGI ID: MGI:1860407
Synonyms: TRbeta-, TRBetaKO
Gene: Thrb  Location: Chr14:4431611-4809435 bp, - strand  Genetic Position: Chr14, 7.08 cM, cytoband A3
Alliance: Thrbtm1Olc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:52829
Parent Cell Line:  ENS (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA cassette containing both a lacZ coding sequence and a neomycin resistance gene was used to replace exons 4 and 5 which code for the DNA binding domain. This insertion inactivates both the beta1 and beta2 isoforms. RT-PCR was used to demonstrate a lack of mRNA in homozygous mutant animals. (J:52829)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 13 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Thrb Mutation:  41 strains or lines available
References
Original:  J:52829 Gauthier K, et al., Different functions for the thyroid hormone receptors TRalpha and TRbeta in the control of thyroid hormone production and post-natal development. EMBO J. 1999 Feb 1;18(3):623-31
All:  34 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory