Thra^tm1Ven
Targeted Allele Detail

Summary

• Symbol: Thra^tm1Ven
• Name: thyroid hormone receptor alpha; targeted mutation 1, Bjorn Vennstrom
• MGI ID: MGI:1860441
• Synonyms: TRalpha1 -, TRalpha1 KO
• Gene: Thra Location: Chr11:98631539-98659832 bp, + strand Genetic Position: Chr11, 62.58 cM, cytoband D-E
• Alliance: Thra^tm1Ven page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:45675
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A gene targeting construct was designed to disrupt the alpha1 isoform, while maintaining the integrity of the alpha2 isoform, as well as the of the orphan hormone receptor rev-erbAalpha that is transcribed on the opposite strand. RT-PCR was used to confirm these results. (J:45675)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Thra Mutation: 40 strains or lines available

References

• Original: J:45675 Wikstrom L, et al., Abnormal heart rate and body temperature in mice lacking thyroid hormone receptor alpha 1. EMBO J. 1998 Jan 15;17(2):455-61
• All: 43 reference(s)