Rela^tm1Yuo
Targeted Allele Detail

Summary

• Symbol: Rela^tm1Yuo
• Name: v-rel reticuloendotheliosis viral oncogene homolog A (avian); targeted mutation 1, Yuichi Obata
• MGI ID: MGI:1860444
• Synonyms: p65^-, relA -
• Gene: Rela Location: Chr19:5687511-5698158 bp, + strand Genetic Position: Chr19, 4.34 cM, cytoband B1-3
• Alliance: Rela^tm1Yuo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63099
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette was inserted 3 base pairs downstream of the translation initiation codon. Northern analysis of total RNA isolated from homozygous mutant embryos showed an absence of transcript. (J:63099)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	67 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Rela Mutation: 28 strains or lines available

References

• Original: J:63099 Doi TS, et al., NF-kappa B RelA-deficient lymphocytes: normal development of T cells and B cells, impaired production of IgA and IgG1 and reduced proliferative responses. J Exp Med. 1997 Mar 3;185(5):953-61
• All: 11 reference(s)