Th^tm1Rpa
Targeted Allele Detail

Summary

• Symbol: Th^tm1Rpa
• Name: tyrosine hydroxylase; targeted mutation 1, Richard D Palmiter
• MGI ID: MGI:1860450
• Synonyms: DA-, pTH4, TH^-
• Gene: Th Location: Chr7:142446516-142453732 bp, - strand Genetic Position: Chr7, 88.06 cM
• Alliance: Th^tm1Rpa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:24347
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A neomycin selection cassette replaced the proximal promoter and exons 1 and 2. (J:24347)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Th Mutation: 58 strains or lines available

References

• Original: J:24347 Zhou QY, et al., Targeted disruption of the tyrosine hydroxylase gene reveals that catecholamines are required for mouse fetal development. Nature. 1995 Apr 13;374(6523):640-3
• All: 14 reference(s)