Adrb3^tm1Lowl
Targeted Allele Detail

Summary

• Symbol: Adrb3^tm1Lowl
• Name: adrenergic receptor, beta 3; targeted mutation 1, Bradford B Lowell
• MGI ID: MGI:1860610
• Synonyms: beta3-AR -
• Gene: Adrb3 Location: Chr8:27715804-27720833 bp, - strand Genetic Position: Chr8, 15.94 cM, cytoband A2-A4
• Alliance: Adrb3^tm1Lowl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:30060
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: FVB/N

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 306bp genomic fragment containing the sequences encoding the third through the fifth transmembrane domains was replaced with a neomycin selection cassette. An RNase protection assay demonstrated that the encoded transcript was not detectable in brown adipose tissue of homozygous mice. (J:30060)

Disease models

Expression

In Mice Carrying this Mutation:	104036 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Adrb3 Mutation: 35 strains or lines available

Notes

This allele was generated by direct injection of DNA vectors into FVB/N zygotes. (J:30060)

References

• Original: J:30060 Susulic VS, et al., Targeted disruption of the beta 3-adrenergic receptor gene. J Biol Chem. 1995 Dec 8;270(49):29483-92
• All: 64 reference(s)