Tlr4^lps-del
Spontaneous Allele Detail

Summary

• Symbol: Tlr4^lps-del
• Name: toll-like receptor 4; defective lipopolysaccharide response, deletion
• MGI ID: MGI:1860755
• Synonyms: Tlr4^-, TLR4-KO, TLR4^lps-
• Gene: Tlr4 Location: Chr4:66745788-66765338 bp, + strand Genetic Position: Chr4, 34.66 cM
• Alliance: Tlr4^lps-del page

Mutation origin

• Strain of Origin: C57BL/10ScN

Mutation description

• Allele Type: Spontaneous (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele has been characterized by lack of mRNA owing to a deletion of the locus. 74723bp of genomic DNA sequence have been removed, encompassing only the Tlr4 gene. (J:51522, J:122203)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 6 strains available Cell Lines: 0 lines available
• Carrying any Tlr4 Mutation: 91 strains or lines available

Notes

C57BL/10ScN, C57BL/10ScNJ, and C57BL10/ScCr mice carry this allele.

References

• Original: J:6086 Vogel SN, et al., Characterization of a congenitally LPS-resistant, athymic mouse strain. J Immunol. 1979 Feb;122(2):619-22
• All: 356 reference(s)