H19^tm1Lda
Targeted Allele Detail

Summary

• Symbol: H19^tm1Lda
• Name: H19, imprinted maternally expressed transcript; targeted mutation 1, Luisa Dandolo
• MGI ID: MGI:1860792
• Synonyms: H19^delta3
• Gene: H19 Location: Chr7:142129267-142131883 bp, - strand Genetic Position: Chr7, 87.97 cM
• Alliance: H19^tm1Lda page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:41236
• Parent Cell Line: CK35 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced 50bp of sequence including the promoter and the entire 3kb transcription unit. (J:41236)
• Inheritance: Dominant

Expression

In Mice Carrying this Mutation:	15 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any H19 Mutation: 12 strains or lines available

Notes

Animals carrying this allele display imprinted expression of the Neo resistance gene.

References

• Original: J:41236 Ripoche MA, et al., Deletion of the H19 transcription unit reveals the existence of a putative imprinting control element. Genes Dev. 1997 Jun 15;11(12):1596-604
• All: 16 reference(s)