Tnf^tm1Jods
Targeted Allele Detail

Summary

• Symbol: Tnf^tm1Jods
• Name: tumor necrosis factor; targeted mutation 1, Johnathon D Sedgwick
• MGI ID: MGI:1860953
• Synonyms: TNF -, TNF^-, TNFalpha^-, TNF-KO
• Gene: Tnf Location: Chr17:35418357-35420983 bp, - strand Genetic Position: Chr17, 18.59 cM
• Alliance: Tnf^tm1Jods page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:43602
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 905 base pairs, encompassing exons 2, 3, and a portion of exon 4, were replaced with a neomycin selection cassette. RT-PCR confirmed the absence of transcript in homozygous mutant mice. (J:43602)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tnf^tm1Jods

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tnf Mutation: 48 strains or lines available

Notes

ES cell lines = BL/6-III and Bruce 4

References

• Original: J:43602 Korner H, et al., Distinct roles for lymphotoxin-alpha and tumor necrosis factor in organogenesis and spatial organization of lymphoid tissue. Eur J Immunol. 1997 Oct;27(10):2600-9
• All: 89 reference(s)