Lta^tm1Jods
Targeted Allele Detail

Summary

• Symbol: Lta^tm1Jods
• Name: lymphotoxin A; targeted mutation 1, Jonathon D Sedgwick
• MGI ID: MGI:1860954
• Synonyms: B6.LTalpha^-, LT alpha -, LTalpha^-
• Gene: Lta Location: Chr17:35422141-35424327 bp, - strand Genetic Position: Chr17, 18.59 cM
• Alliance: Lta^tm1Jods page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:47428
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted into exon 2 of the gene. RT-PCR of PMA-activated splenocytes from homozygous mutant mice showed no detectable mRNA for the targeted gene. (J:47428)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lta Mutation: 17 strains or lines available

References

• Original: J:47428 Sean Riminton D, et al., Challenging cytokine redundancy: inflammatory cell movement and clinical course of experimental autoimmune encephalomyelitis are normal in lymphotoxin-deficient, but not tumor necrosis factor-deficient, mice. J Exp Med. 1998 May 4;187(9):1517-28
• All: 29 reference(s)