Ltb^tm1Flv
Targeted Allele Detail

Summary

• Symbol: Ltb^tm1Flv
• Name: lymphotoxin B; targeted mutation 1, Richard A Flavell
• MGI ID: MGI:1860955
• Synonyms: LT beta-, LTbeta-
• Gene: Ltb Location: Chr17:35413483-35415281 bp, + strand Genetic Position: Chr17, 18.59 cM
• Alliance: Ltb^tm1Flv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:39746
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced a 0.7 kb fragment of the gene, truncating the coding sequence at codon 153. Northern blots of total RNA from splenocytes from homozygous mutant mice showed an absence of mRNA for the targeted gene. (J:39746, J:95222)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ltb Mutation: 19 strains or lines available

References

• Original: J:39746 Koni PA, et al., Distinct roles in lymphoid organogenesis for lymphotoxins alpha and beta revealed in lymphotoxin beta-deficient mice. Immunity. 1997 Apr;6(4):491-500
• All: 34 reference(s)