Lta^tm1Tab
Targeted Allele Detail

Summary

• Symbol: Lta^tm1Tab
• Name: lymphotoxin A; targeted mutation 1, Theresa A Banks
• MGI ID: MGI:1860957
• Synonyms: LT-alpha-, LTalpha^-
• Gene: Lta Location: Chr17:35422141-35424327 bp, - strand Genetic Position: Chr17, 18.59 cM
• Alliance: Lta^tm1Tab page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:28061
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced a portion of exon 2, all of exon 3, and a portion of exon 4 of the gene. Southern blots confirmed absence of both wild-type alleles in homozygous mutant mice. RT-PCR of Con A-stimulated splenocytes from homozygous mutant mice showed no detectable mRNA for the targeted gene. (J:28061)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lta Mutation: 17 strains or lines available

References

• Original: J:28061 Banks TA, et al., Lymphotoxin-alpha-deficient mice. Effects on secondary lymphoid organ development and humoral immune responsiveness. J Immunol. 1995 Aug 15;155(4):1685-93
• All: 15 reference(s)