Hfm
Transgenic Allele Detail

Summary

• Symbol: Hfm
• Name: hemifacial microsomia-associated locus
• MGI ID: MGI:1861103
• Synonyms: 643-7, microtia, Tg(MBP)643Mok
• Gene: Hfm Location: unknown Genetic Position: Chr10, cytoband B1-3
• Alliance: Hfm page

Transgene origin

• Strain of Origin: SWV-Mbp^shi

Transgene description

• Transgene Type: Transgenic
• Mutations: Deletion, Insertion
• Hfm involves 1 genes/genome features (Hfm) View all
• Mutation details: A 23 Kb deletion on chromosome 10 occurred at the integration site of a transgene that expressed myelin basic protein. (J:21097)
• Inheritance: Dominant

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hfm Mutation: 0 strains or lines available

Notes

This mutation was generated by by pronuclear injection of a transgene into SWV-Mbp^shi fertilized oocytes. Approximately 50-100 copies initially inserted into this locus, but the copy number decreased to 1 or a few during the course of breeding. This decrease of copy number had no effect on the phenotype. Some mice were mated to a B6C female to expand to an F3 generation.

References

• Original: J:77548 Kimura M, et al., Restoration of myelin formation by a single type of myelin basic protein in transgenic shiverer mice. Proc Natl Acad Sci U S A. 1989 Jul;86(14):5661-5
• All: 3 reference(s)