Klf1^Nan
Chemically induced Allele Detail

Summary

• Symbol: Klf1^Nan
• Name: Kruppel-like transcription factor 1 (erythroid); neonatal anemia
• MGI ID: MGI:1861107
• Synonyms: Nan
• Gene: Klf1 Location: Chr8:85628611-85631920 bp, + strand Genetic Position: Chr8, 41.3 cM
• Alliance: Klf1^Nan page

Mutation origin

• Strain of Origin: PT x (C3H/HeH x 101/H)F1

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: An A-to-T transversion at base pair 1064 (reference sequence NM_010635) in exon 3 changes glutamic acid to aspartic acid (p.E339D) within the second zinc finger required for DNA binding in the encoded protein. (J:163685)
• Inheritance: Semidominant

Disease models

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Klf1 Mutation: 22 strains or lines available

References

• Original: J:13933 Lyon MF, et al., Dominant haemolytic anemia. Mouse News Lett. 1983;68:68
• All: 11 reference(s)