Il1r1^tm1Imx
Targeted Allele Detail

Summary

• Symbol: Il1r1^tm1Imx
• Name: interleukin 1 receptor, type I; targeted mutation 1, Immunex Research and Development Corporation
• MGI ID: MGI:1861112
• Synonyms: IL-1R^-, IL-1R1-, Il1r1^tm1jmx, IL-1RI KO, Il1r^tm1Imx, IL-R1^-, RIko
• Gene: Il1r1 Location: Chr1:40264240-40356417 bp, + strand Genetic Position: Chr1, 18.81 cM
• Alliance: Il1r1^tm1Imx page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:43088
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced two exons of the gene, which encode amino acids 4 - 225 of the mature protein. (J:43088)

Disease models

Expression

In Mice Carrying this Mutation:	10 assay results
In Structures Affected by this Mutation:	10 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Il1r1^tm1Imx

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Il1r1 Mutation: 39 strains or lines available

References

• Original: J:43088 Glaccum MB, et al., Phenotypic and functional characterization of mice that lack the type I receptor for IL-1. J Immunol. 1997 Oct 1;159(7):3364-71
• All: 423 reference(s)