In(15)4H
Radiation induced Allele Detail

Summary

• Symbol: In(15)4H
• Name: inversion, Chr 15, Harwell 4
• MGI ID: MGI:1861120
• Synonyms: Koa, koala
• Gene: In(15)4H Location: unknown Genetic Position: Chr15, Syntenic

Mutation origin

• Strain of Origin: C3H/HeH

Mutation description

• Allele Type: Radiation induced
• Mutation: Inversion
• In(15)4H involves 782 genes/genome features (Eif3h, Utp23, Rad21 ...) View all
• Mutation details: Male C3H/HeH mice received a fractionated dose of (3 + 3) Gy X-rays. Mitotic studies of G-banded chromosomes show that this mutation is associated with a paracentric inversion extending from 15D2 to 15F. Expression of Trps1 which is 0.8Mb proximal to the proximal breakpoint of this inversion is markedly reduced while expression of no other candidate genes near the break points are affected. (J:103253, J:121991, J:141036, J:155838)
• Inheritance: Dominant

Disease models

Expression

In Mice Carrying this Mutation:	43 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any In(15)4H Mutation: 1 strain or line available

References

• Original: J:14236 Ball ST, et al., Koala, a dominant mutation. Mouse News Lett. 1989;83:163-4
• All: 6 reference(s)