Cdh2^tm1Hyn
Targeted Allele Detail

Summary

• Symbol: Cdh2^tm1Hyn
• Name: cadherin 2; targeted mutation 1, Richard Hynes
• MGI ID: MGI:1861181
• Synonyms: Cdh2^-, N-cadherin^-, Ncad^neo
• Gene: Cdh2 Location: Chr18:16721934-16942303 bp, - strand Genetic Position: Chr18, 10.1 cM
• Alliance: Cdh2^tm1Hyn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:37888
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin cassette was inserted into the exon 10, which encodes part of the extracellular domain of the protein. The protein was untectectable in Western blots of protein lysates derived from homozygous mutant embryos. (J:37888)

Expression

In Mice Carrying this Mutation:	123 assay results
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cdh2 Mutation: 51 strains or lines available

References

• Original: J:37888 Radice GL, et al., Developmental defects in mouse embryos lacking N-cadherin. Dev Biol. 1997 Jan 1;181(1):64-78
• All: 21 reference(s)