Shh^Dsh
Radiation induced Allele Detail

Summary

• Symbol: Shh^Dsh
• Name: sonic hedgehog; short digits
• MGI ID: MGI:1861186
• Synonyms: Dsh, short digits
• Gene: Shh Location: Chr5:28661838-28672099 bp, - strand Genetic Position: Chr5, 14.39 cM
• Alliance: Shh^Dsh page

Mutation origin

• Strain of Origin: (101 x C3H)F1

Mutation description

• Allele Type: Radiation induced
• Mutation: Inversion
• Shh^Dsh involves 138 genes/genome features (Gm42230, Cdhr17, Gm6673 ...) View all
• Mutation details: The short digits mutation was shown to be allelic to Shh mutations by an alleleism test (Stefan Mundlos, unpublished, see also J:67151). This mutation is an inversion comprising 11.7 Mb. The distal breakpoint is 13.298 kb upstream of Shh, separating the coding sequence from several putative regulatory elements. The inversion results in dysregulated expression of Shh resulting in the mutant phenotype. (J:97323)
• Inheritance: Semidominant

Disease models

Expression

In Mice Carrying this Mutation:

21 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Shh Mutation: 48 strains or lines available

References

• Original: J:14105 Selby P, et al., Short digits, a new mutation. Mouse News Lett. 1986;75:43
• All: 5 reference(s)